Review of United States Patent # 6,630,507
*But Wait! Isn't this the same substance they claim is a "Schedule I Narcotic with no known medicinal value"?
For confirmation from the author, Dr Allen, please contact him at 510-421-6179 or email him [email protected] This was sent by email to Senator Deborah Dawkins of Mississippi. You may reprint it as much as possible - 2/26/12
Senator Dawkins;
My name is David B. Allen M.D.. I had previously sent you a copy of my press release. I expect you have received it.
I am writing you to direct your attention on a United States Patent 6,630,507 of Cannabinoids as Antioxidants and Neruoprotectants.(attached). The Patent is quite complex and hard to read for most lay public. I am a professional scientific journal reviewer by my credentials as a heart surgeon. This Patent; which by acceptance by the patent office, is evidence that everything contained in that patent is considered the Truth. If you look on page 17 (of 26 total pages) and read column 16 under example 7 in vivo rat studies line 60 thru 63 it states the following; "This data shows that infarct size (the size of the Stroke) was approximately halved in the animals treated with Cannabidiol, which was also accompanied by a substantial improvement in the neurological status of the animal."
This is proof by the governments own hand, that Cannabidiol and THC both Decrease the size of a stroke by 50%! Since Cannabidiol is extremely safe in large doses in humans and does not have any euphoric effects (doesn’t get you high); It would not change the physical exam of a patient having a stroke, and could be used without masking any change in the neurologic status.
Each year there are 800,000 strokes in the United States, of these 150,000 die and the rest are left to suffer the consequences of the stroke. A 50% reduction in a stroke would be a miracle as no other drug available today can decrease stroke size by any percent. (clot busters excluded) The difference of 50% reduction would mean the difference between the stroke victim being able to walk or not or talk or not. The monetary savings in health care and the human suffering make this issue too important to ignore.
Based on this US Patent and the safety factor of Cannabidiol there is no excuse for not doing clinical phase 3 human trials. I suspect many people would volunteer to receive this safe drug if they had a chance to reduce their stroke by 50%. I know I would. This medicine Cannabidiol could be available as a urgent as needed basis or as a daily supplement in high risk patients. The chances of drug diversion of this medication would be ZERO.
This is no mistake; There is also evidence in the British Journal of Pharmacology entitled
“Acute administration of Cannabidiol in vivo suppresses ischaemia-induced cardiac arrhythmias and reduces infarct size when given at reperfusion.” (also attached) This complex title states Cannabidiol reduces arrhythmias caused by low blood flow and decreases the size of the myocardial infarction. This study in and of itself, is not proof, but is very good evidence, that heart attacks are also diminished by approximately 50%! Please see figure 3 pp 1238 of the Patent...
This is copy from the study;
Effect of CBD on infarct size
Figure 3 illustrates the effects of the higher dose of CBD (50 mg•kg-1) on both area at risk (percentage of left ventricular area) and infarct size (percentage of area at risk). Area at risk was similar across all groups. Administration of CBD (50 mg•kg-1) prior to coronary occlusion significantly reduced infarct size, as did its administration immediately prior to reperfusion, when compared with vehicle-treated control rats (both P 0.001; Figure 3).
In my opinion the study is not well written and they do not state exact percent of heart muscle saved but figure 3 shows about 50% reduction. (see attachment)
I have read the adverse articles printed in the local Mississippi newspapers about Mississippi Medical Marijuana bill (Bill 2252). The above information is not known to the public and would silence anyone who thinks there is no medical utility for cannabis. This is of course only a small application of the medical utility of cannabis. (Marijuana is improper terminology)
I would like to further discuss many more articles showing proof of medical utility of Cannabis, and absents of harm. I have NIH studies that show improvement in reaction time of Drivers using cannabis.
No one can deny the science. Cannabis is not only a medicine,; It is Life Saving Medicine! This medicine will be used legally here in California with great benefit, but this benefit may be unnoticed. We need to allow formal Clinical trials but this is not possible in today's political environment. There is a virtual moratorium of free scientific medical study of cannabis in the United States. Many studies could be done with little risk to patients and to delineate the potentials of this medicine. The patients are already using the medicine, we just have to do organized study of them.
This Medicine will be used legally in California and in states who's LAWMAKERS do not prevent sick and dying patients from receiving this life saving medication. I suspect that once the medical utility is proven without doubt that no politician will want to have been on the side of the law that incarcerated citizens for using life saving medicine. Cannabis prohibition cannot stand much longer. The science is behind this miraculous plant.
I write this letter not because I have anything to gain. I write this letter because I have suffered because of the unjust laws that hurt our society. It is past time to end the suffering of the illnesses and suffering from the laws.
I pray this letter is a National call to reason.
Romans 14:2 For one believes that he may eat all things: another who is weak eats herbs.
Romans 14:3 Let not him that eats (herbs) despise him that eats not;
And let not him which eateth not (herbs) Judge him that eateth.
King James ver.
By this very statement in the bible it is religious persecution to incarcerate me for herbs.
I urge you to introduce legislation to end the prohibition of scientific research on Cannabis caused by the Conspiracy of the Drug War Proponents.
Thank you for helping the stroke and heart attack patients.
David B. Allen M.D.
*But Wait! Isn't this the same substance they claim is a "Schedule I Narcotic with no known medicinal value"?
For confirmation from the author, Dr Allen, please contact him at 510-421-6179 or email him [email protected] This was sent by email to Senator Deborah Dawkins of Mississippi. You may reprint it as much as possible - 2/26/12
Senator Dawkins;
My name is David B. Allen M.D.. I had previously sent you a copy of my press release. I expect you have received it.
I am writing you to direct your attention on a United States Patent 6,630,507 of Cannabinoids as Antioxidants and Neruoprotectants.(attached). The Patent is quite complex and hard to read for most lay public. I am a professional scientific journal reviewer by my credentials as a heart surgeon. This Patent; which by acceptance by the patent office, is evidence that everything contained in that patent is considered the Truth. If you look on page 17 (of 26 total pages) and read column 16 under example 7 in vivo rat studies line 60 thru 63 it states the following; "This data shows that infarct size (the size of the Stroke) was approximately halved in the animals treated with Cannabidiol, which was also accompanied by a substantial improvement in the neurological status of the animal."
This is proof by the governments own hand, that Cannabidiol and THC both Decrease the size of a stroke by 50%! Since Cannabidiol is extremely safe in large doses in humans and does not have any euphoric effects (doesn’t get you high); It would not change the physical exam of a patient having a stroke, and could be used without masking any change in the neurologic status.
Each year there are 800,000 strokes in the United States, of these 150,000 die and the rest are left to suffer the consequences of the stroke. A 50% reduction in a stroke would be a miracle as no other drug available today can decrease stroke size by any percent. (clot busters excluded) The difference of 50% reduction would mean the difference between the stroke victim being able to walk or not or talk or not. The monetary savings in health care and the human suffering make this issue too important to ignore.
Based on this US Patent and the safety factor of Cannabidiol there is no excuse for not doing clinical phase 3 human trials. I suspect many people would volunteer to receive this safe drug if they had a chance to reduce their stroke by 50%. I know I would. This medicine Cannabidiol could be available as a urgent as needed basis or as a daily supplement in high risk patients. The chances of drug diversion of this medication would be ZERO.
This is no mistake; There is also evidence in the British Journal of Pharmacology entitled
“Acute administration of Cannabidiol in vivo suppresses ischaemia-induced cardiac arrhythmias and reduces infarct size when given at reperfusion.” (also attached) This complex title states Cannabidiol reduces arrhythmias caused by low blood flow and decreases the size of the myocardial infarction. This study in and of itself, is not proof, but is very good evidence, that heart attacks are also diminished by approximately 50%! Please see figure 3 pp 1238 of the Patent...
This is copy from the study;
Effect of CBD on infarct size
Figure 3 illustrates the effects of the higher dose of CBD (50 mg•kg-1) on both area at risk (percentage of left ventricular area) and infarct size (percentage of area at risk). Area at risk was similar across all groups. Administration of CBD (50 mg•kg-1) prior to coronary occlusion significantly reduced infarct size, as did its administration immediately prior to reperfusion, when compared with vehicle-treated control rats (both P 0.001; Figure 3).
In my opinion the study is not well written and they do not state exact percent of heart muscle saved but figure 3 shows about 50% reduction. (see attachment)
I have read the adverse articles printed in the local Mississippi newspapers about Mississippi Medical Marijuana bill (Bill 2252). The above information is not known to the public and would silence anyone who thinks there is no medical utility for cannabis. This is of course only a small application of the medical utility of cannabis. (Marijuana is improper terminology)
I would like to further discuss many more articles showing proof of medical utility of Cannabis, and absents of harm. I have NIH studies that show improvement in reaction time of Drivers using cannabis.
No one can deny the science. Cannabis is not only a medicine,; It is Life Saving Medicine! This medicine will be used legally here in California with great benefit, but this benefit may be unnoticed. We need to allow formal Clinical trials but this is not possible in today's political environment. There is a virtual moratorium of free scientific medical study of cannabis in the United States. Many studies could be done with little risk to patients and to delineate the potentials of this medicine. The patients are already using the medicine, we just have to do organized study of them.
This Medicine will be used legally in California and in states who's LAWMAKERS do not prevent sick and dying patients from receiving this life saving medication. I suspect that once the medical utility is proven without doubt that no politician will want to have been on the side of the law that incarcerated citizens for using life saving medicine. Cannabis prohibition cannot stand much longer. The science is behind this miraculous plant.
I write this letter not because I have anything to gain. I write this letter because I have suffered because of the unjust laws that hurt our society. It is past time to end the suffering of the illnesses and suffering from the laws.
I pray this letter is a National call to reason.
Romans 14:2 For one believes that he may eat all things: another who is weak eats herbs.
Romans 14:3 Let not him that eats (herbs) despise him that eats not;
And let not him which eateth not (herbs) Judge him that eateth.
King James ver.
By this very statement in the bible it is religious persecution to incarcerate me for herbs.
I urge you to introduce legislation to end the prohibition of scientific research on Cannabis caused by the Conspiracy of the Drug War Proponents.
Thank you for helping the stroke and heart attack patients.
David B. Allen M.D.
us_cannibinoids_patent_review_dr_david_b_allen_m.d..odt | |
File Size: | 7 kb |
File Type: | odt |
US Patent 7109245 - Vasoconstrictor cannabinoid analogs
Abstract - Cannabinoids have been found to have antioxidant properties, unrelated to NMDA receptor antagonism. This new found property makes cannabinoids useful in the treatment and prophylaxis of wide variety of oxidation associated diseases, such as ischemic, age-related, inflammatory and autoimmune diseases. The cannabinoids are found to have particular application as neuroprotectants, for example in limiting neurological damage following ischemic insults, such as stroke and trauma, or in the treatment of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and HIV dementia. Nonpsychoactive cannabinoids, such as cannabidoil, are particularly advantageous to use because they avoid toxicity that is encountered with psychoactive cannabinoids at high doses useful in the method of the present invention. A particular disclosed class of cannabinoids useful as neuroprotective antioxidants is formula (I) wherein the R group is independently selected from the group consisting of H, CH3, and COCH3. ##STR1#
Other References
Inventors
The United States of America as represented by the Department of Health and Human Services
ApplicationNo. 09/674028 filed on 02/02/2001
US Classes:514/454
Field of Search514/454
ExaminersPrimary: Weddington, Kevin E.
Attorney, Agent or Firm
US Patent References2304669, 4876276, 5227537,5284867, 5434295, 5462946,5512270, 5521215, 5538993,5635530, 5696109, 6410588
International ClassA61K 31/35 (20060101)
Comments:
Anything to stop the US citizen from getting natures CURE for cancer and hundreds if not thousands of other diseases without throwing money in the pockets of pharma now for their unnatural pills or later for cannabis cures in exchange for insane amounts of moneys or for the elite allowed to survive;
by Jimon 01/27/2010 11:09 AM this is just the tip of the iceberg gentelmen , the greed of this government is why it isn't legal, the government can do as they want and what are we going to do about it ? scream to loud and they will squash you like a bug, some how we need to get this out to everyone in the usa so they to can see how the government lies to us all.. They are no longer there to do as we say , there there for greed and how much money they can steel from the people:
by Kevin M. Joneson 12/17/2009 10:21 AM"Nonpsychoactive cannabinoids, such as cannabidoil, are particularly advantageous to use because they avoid "TOXICITY" that is encountered with psychoactive cannabinoids at high doses useful in the method of the present invention." Isn't the patent office suposed to, by law, through the process, protect us from fraudulent, inacurate, and Unsubsstantiated claims made within any patent? Somebody help me here, is there a single TOXIC cannabinoid? If so, please name it and spread the word;
by balanceon 09/24/2009 03:38 PMHere's another cannabinoid related patent with assignee: United States of America. This one relates to vasoconstrictor properties. http://www.patentstorm.us/patents/7109245/fulltext.html There are hundreds of cannabinoid related patents issued. Most to universities and parma companies;
by James Bongon 09/20/2009 10:29 AMYou can't patent cannabis any more than you can patent the multiplication tables or mockingbirds. Patents have to be unique inventions, not attempts to monopolize nature or logic. They also should have absolutely nothing to do with fascism, enforced misery, torture, or a police state, which seems to be the intent here. This ruling is emminently challengable in the Patent Court, and the citizenry should waste no time in ousting this abortion of a patent ruling from the Patent office, where it has no place at all. There are limits to the patentability of objects, and nearly all of them have been exceeded here, for a multiplicity of reasons;
by Doobzon 09/18/2009 08:38 AMWhy is there no "Flag patent as inappropriate" check-box?by Seriously?
on 08/17/2009 06:35 AM Is this some type of brilliant hoax to discredit the U.S. government's stance on marijuana as a useful medicine? Dr. Jekyll, may I introduce Mr. Hyde (the truth);
by motamorfosison 07/25/2009 07:59 AMthis makes me sick that our nation is so greedy that they have patented cannabis. obviously they are convinced it has medical value. but for now the greedy prisons, DEA, & judicial system make too much money. the BIG PHARMA, TOBACCO, PAPER, ALCOHOL COmpanies make too much money as do their congressman funded via the respective lobbyists. we’re not taking it anymore. yes we cannabis & HEMP 2010 throughout the americas;
by Mikeyon 07/23/2009 09:13 PMWhy don't you patent water or oxygen. How about Wheat, then no one in the world can have bread without getting a license. WTF?
by markon 05/06/2009 02:20 PM well the u.s. holds a patent on cannabanoids.there is nothing in the law that says they must produce .so in other words yea we have it but will not use so what !!! 1 2 3 Next» Last»
Abstract - Cannabinoids have been found to have antioxidant properties, unrelated to NMDA receptor antagonism. This new found property makes cannabinoids useful in the treatment and prophylaxis of wide variety of oxidation associated diseases, such as ischemic, age-related, inflammatory and autoimmune diseases. The cannabinoids are found to have particular application as neuroprotectants, for example in limiting neurological damage following ischemic insults, such as stroke and trauma, or in the treatment of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and HIV dementia. Nonpsychoactive cannabinoids, such as cannabidoil, are particularly advantageous to use because they avoid toxicity that is encountered with psychoactive cannabinoids at high doses useful in the method of the present invention. A particular disclosed class of cannabinoids useful as neuroprotective antioxidants is formula (I) wherein the R group is independently selected from the group consisting of H, CH3, and COCH3. ##STR1#
Other References
- Windholz et al., The Merck Index, Tenth Edition (1983) p. 241, abstract No. 1723.
- Mechoulam et al., "A Total Synthesis of d1-Ɗ1 -Tetrahydrocannabinol, the Active Constituent of Hashish1," Journal of the American Chemical Society, 87:14:3273-3275 (1965)
- Mechoulam et al., "Chemical Basis of Hashish Activity," Science, 18:611-612 (1970)
- Ottersen et al., "The Crystal and Molecular Structure of Cannabidiol," Acta Chem. Scand. B 31, 9:807-812 (1977)
- Cunha et al., "Chronic Administration of Cannabidiol to Healthy Volunteers and Epileptic Patients1," Pharmacology, 21:175-185 (1980)
- Consroe et al., "Acute and Chronic Antiepileptic Drug Effects in Audiogenic Seizure-Susceptible Rats," Experimental Neurology, Academic Press Inc., 70:626-637 (1980)
- Turkanis et al., "Electrophysiologic Properties of the Cannabinoids," J. Clin. Pharmacol., 21:449S-463S (1981)
- Carlini et al., "Hypnotic and Antielpileptic Effects of Cannabidiol," J. Clin. Pharmacol., 21:417S-427S (1981)
- Karler et al., "The Cannabinoids as Potential Antiepileptics," J. Clin. Pharmacol., 21:437S-448S (1981)
- Consroe et al., "Antiepileptic Potential of Cannabidiol Analgos," J. Clin. Pharmacol., 21:428S-436S (1981)
- Colasanti et al., "Ocular Hypotension, Ocular Toxicity,a nd Neurotoxicity in Response to Marihuana Extract and Cannabidiol," Gen Pharm., Pergamon Press Ltd., 15(6):479-484 (1984)
- Colasanti et al., "Intraocular Pressure, Ocular Toxicity and Neurotoxicity after Administration of Cannabinol or Cannabigerol," Exp. Eye Res., Academic Press Inc., 39:251-259 (1984)
- Volfe et al., "Cannabinoids Block Release of Serotonin from Platelets Induced by Plasma frm Migraine Patients," Int. J. Clin. Pharm. Res., Bioscience Ediprint Inc., 4:243-246 (1985)
- Agurell et al., "Pharmacokinetics and Metabolism of Ɗ1 -Tetrahydrocannabinol and Other Cannabinoids with Emphasis on Man*," Pharmacological Reviews, 38(1):21-43 (1986)
- Karler et al., "Different Cannabinoids Exhibit Different Pharmacological and Toxicological Properties,"NIDA Res. Monogr., 79:96-107 (1987)
- Samara et al., "Pharmacokinetics of Cannabidiol in Dogs," Drug Metabolism and Disposition, 16(3):469-472 (1988)
- Choi, "Glutamate Neurotoxicity and Diseases of the Nervous System," Neuron, Cell Press, 1:623-634 (1988)
- Eshhar et al., "Neuroprotective and Antioxidant Activities of HU-211, A Novel NMDA Receptor Antagonist," European Journal of Pharmacology, 283:19-29 (1995)
- Skaper et al., "The ALIAmide Palmitoylethanolamide and Cannabinoids, but not Anandamide, are Protective in a Delayed Postglutamate Paradigm of Excitotoxic Death in Cerebellar Granule Neurons," Neurobiology, Proc. Natl. Acad. Sci. USA, 93:3984-3989 (1996)
- Alonso et al., "Simple Synthesis of 5-Substituted Resorcinols: A Revisited Family of Interesting Bioactive Molecules," J. Org. Chem., American Chemical Society, 62(2):417-421 (1997)
- Combes et al. "A Simple Synthesis of the Natural 2,5-Dialkylresorcinol Free Radical Scavenger Antioxidant: Resorstation," Synthetic Communications, Marcel Dekker, Inc., 27(21):3769-3778 (1997)
- Shohami et al., "Oxidative Stress in Closed-Head Injury: Brain Antioxidant Capacity as an Indicator of Functional Outcome," Journal of Cerebral Blood Flow and Metabolism, Lippincott-Raven Publishers, 17(10):1007-1019 (1997)
- Zurier et al., "Dimethylheptyl-THC-11 OIC Acid," Arthritis & Rheumatism, 41(1):163-170 (1998)
- Hampson et al., "Dual Effects of Anandamide on NMDA Receptor-Mediated Responses and Neurotransmission," Journal of Neurochemistry, Lippincott-Raven Publishers, 70(2):671-676 (1998)
- Hampson et al., "Cannabidiol and (-)Ɗ9 -tetrahydrocannabiono are Neuroprotective Antioxidants," Medical Sciences, Proc. Natl. Acad. Sci. USA, 8268-8273 (1998)
Inventors
The United States of America as represented by the Department of Health and Human Services
ApplicationNo. 09/674028 filed on 02/02/2001
US Classes:514/454
Field of Search514/454
ExaminersPrimary: Weddington, Kevin E.
Attorney, Agent or Firm
US Patent References2304669, 4876276, 5227537,5284867, 5434295, 5462946,5512270, 5521215, 5538993,5635530, 5696109, 6410588
International ClassA61K 31/35 (20060101)
Comments:
Anything to stop the US citizen from getting natures CURE for cancer and hundreds if not thousands of other diseases without throwing money in the pockets of pharma now for their unnatural pills or later for cannabis cures in exchange for insane amounts of moneys or for the elite allowed to survive;
by Jimon 01/27/2010 11:09 AM this is just the tip of the iceberg gentelmen , the greed of this government is why it isn't legal, the government can do as they want and what are we going to do about it ? scream to loud and they will squash you like a bug, some how we need to get this out to everyone in the usa so they to can see how the government lies to us all.. They are no longer there to do as we say , there there for greed and how much money they can steel from the people:
by Kevin M. Joneson 12/17/2009 10:21 AM"Nonpsychoactive cannabinoids, such as cannabidoil, are particularly advantageous to use because they avoid "TOXICITY" that is encountered with psychoactive cannabinoids at high doses useful in the method of the present invention." Isn't the patent office suposed to, by law, through the process, protect us from fraudulent, inacurate, and Unsubsstantiated claims made within any patent? Somebody help me here, is there a single TOXIC cannabinoid? If so, please name it and spread the word;
by balanceon 09/24/2009 03:38 PMHere's another cannabinoid related patent with assignee: United States of America. This one relates to vasoconstrictor properties. http://www.patentstorm.us/patents/7109245/fulltext.html There are hundreds of cannabinoid related patents issued. Most to universities and parma companies;
by James Bongon 09/20/2009 10:29 AMYou can't patent cannabis any more than you can patent the multiplication tables or mockingbirds. Patents have to be unique inventions, not attempts to monopolize nature or logic. They also should have absolutely nothing to do with fascism, enforced misery, torture, or a police state, which seems to be the intent here. This ruling is emminently challengable in the Patent Court, and the citizenry should waste no time in ousting this abortion of a patent ruling from the Patent office, where it has no place at all. There are limits to the patentability of objects, and nearly all of them have been exceeded here, for a multiplicity of reasons;
by Doobzon 09/18/2009 08:38 AMWhy is there no "Flag patent as inappropriate" check-box?by Seriously?
on 08/17/2009 06:35 AM Is this some type of brilliant hoax to discredit the U.S. government's stance on marijuana as a useful medicine? Dr. Jekyll, may I introduce Mr. Hyde (the truth);
by motamorfosison 07/25/2009 07:59 AMthis makes me sick that our nation is so greedy that they have patented cannabis. obviously they are convinced it has medical value. but for now the greedy prisons, DEA, & judicial system make too much money. the BIG PHARMA, TOBACCO, PAPER, ALCOHOL COmpanies make too much money as do their congressman funded via the respective lobbyists. we’re not taking it anymore. yes we cannabis & HEMP 2010 throughout the americas;
by Mikeyon 07/23/2009 09:13 PMWhy don't you patent water or oxygen. How about Wheat, then no one in the world can have bread without getting a license. WTF?
by markon 05/06/2009 02:20 PM well the u.s. holds a patent on cannabanoids.there is nothing in the law that says they must produce .so in other words yea we have it but will not use so what !!! 1 2 3 Next» Last»